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TtGG Ancestry Testing Module

The Ancestry Testing module teaches students quantitative and data analysis skills through the engaging story of a high school student exploring ancestry DNA testing, while also incorporating bioethics and career exploration.

Module Description

The Ancestry Testing module aims to teach quantitative and data analysis skills in the context of genetics and bioinformatics. This module introduces students to the concept of ancestry DNA testing, using a narrative to frame the learning activities. Students will follow the fictional story of Sam, a high school student who wants an at-home ancestry DNA test for their 18th birthday.

In addition to the biology concepts introduced, students will use quantitative skills to calculate DNA variations in individuals and across populations. They will also interpret and explain results, such as associating individuals with geographic populations. Each part of the Ancestry Testing module also includes accompanying sections on bioethics and career exploration, which can be incorporated as part of the activity or used separately. In each Ethics section, students will connect social and cultural themes to the biology concepts in the activity through research, reflections, predictions, discussions, and/or debates. In each Careers section, students will perform self-directed exploration of jobs associated with the learning topics in the main activity.

Learning Objectives

Essential Questions
  1. How does ancestry testing work?  
  2. Why do ancestry test results change?  
  3. What do ancestry test results mean, for me, for my family, for my health?  
  4. How does my ancestral DNA information connect with my identity? 
Enduring Understandings
  1. DNA is inherited (and lost) across generations, such that not all genealogical ancestors are genetic ancestors. 
  2. Ancestry testing typically involves sequencing of genomic single nucleotide variants. 
  3. Reference genomes for ancestry tests are comprised of aggregate single nucleotide variant data from varying numbers of individuals. 
  4. Ancestry information can inform about personal and family history and health outcomes.  

NGSS Alignments

Coming Soon!

Teacher Resources

Lesson Plan
Teacher Guide

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Student Activities

Digital Download
Introduction to Ancestry Testing

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Digital Download
Sequence Comparison in Ancestry Testing (Paper)

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Digital Download
Sequence Comparison in Ancestry Testing (Spreadsheet)

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Supplemental Resources

What are DNA Variants?

Minute to Understanding: What are DNA variants?

Explore DNA variants and discover how mutations during DNA replication make each organism unique. Learn about their role in genetic variation and their potential impact on life.

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