Employs mouse models of human eye disease to study gene function and mechanisms underlying disease pathology.
Employs mouse models of human eye disease to study gene function and mechanisms underlying disease pathology.
We have used mouse models as an entry point to identify molecules that are essential for normal retinal development and function through positional cloning efforts. We are now using these models to study the gene function and complex mechanisms underlying disease pathways, with a focus on genetic background effects, genetic modifiers and interaction partners.
